“Native Ion Mobility-Mass Spectrometry of Biomolecular Complexes”, Assoc. Prof. James S. Prell, Chemistry
Native ion mobility-mass spectrometry (IM-MS) uses the chemical specificity, high sensitivity, and speed of gas-phase methods to probe the composition, structure, and behavior of folded biomolecules and biomolecular complexes from the condensed phase. Because these analytes can often be polydisperse and heterogeneous, new methods are needed for disentangling the information that can be rapidly learned using native IM-MS, including speciation, reaction kinetics, and formation mechanisms.
Our REU student will prepare samples for native IM-MS analysis, operate state-of-the-art IM-MS instrumentation, interpret data using novel algorithms developed in our group, and perform simulations as necessary for data interpretation with the guidance of a graduate student mentor. Participants will benefit from a solid background in undergraduate physics, chemistry, and/or biochemistry.