Pluth

Developing New Chemical Tools for Chemical Biology
Michael Pluth, Chemistry
Research in the Pluth group is thematically based on different aspects of molecular recognition at the interface of chemistry and biology. Our group uses synthetic chemistry to enable new investigations into chemical biology and catalysis. We use a variety of synthetic (organic, inorganic, air-free) and spectroscopic (NMR, UV-vis, fluorescence, microscopy) techniques to prepare, characterize, and test our developed scaffolds. glovebox1Current areas of research focus on using chemistry as a tool to understand the biological functions of H2S and other small sulfur-containing biomolecules. Aligned with these foci, primary areas for current REU projects include the development of new chemical tools for H2S detection and quantification; using bioinorganic model chemistry to investigate H2S reactivity; and developing slow-releasing COS/H2S donors. These projects provide the opportunity to learn a variety of techniques in organic chemistry, chemical biology, and compound characterization in an interdisciplinary research environment.